Mass spectrometry or MS is an investigative method that ionizes compound species and arranges the ions on the basis of their mass-to-charge ratio. In layman terms, mass spectrum calculates the masses inside a sample. A mass spectrum is basically a plot of the signal that is generated by the ion with respect to the mass-to-charge ratio. The spectra thus generated are used to detect the isotopic or elemental signature of samples such as peptides and other chemical compounds. Mass spectrometry finds application in various fields such as atom probe, protein characterization, and glycane analysis, among others. However, the clinical mass spectrometry market has a promising future, owing to the preciseness of the process as well as technological advancements in the field of pharmacokinetics.
Clinical mass spectrometry is widely used for diagnostic purposes. Outside the usage of mass spectrometry in the routine diagnostic setting, clinical mass spectrometry also deals with the conversion of analytical research and experimental techniques to patients' care and its applications in routine patient care studies and clinical research. The scope of clinical mass spectrometry includes endocrinology, therapeutic drug monitoring, microbiology, regulatory aspects in diagnostic usages, and patient safety and risk assessment, among others.
Clinical mass spectrometry has gained significant prominence over the last decade, with large clinical laboratories adopting LC-MS/MS or liquid chromatography-tandem mass spectrometry. These mainly use reverse phase liquid chromatography at conformist flow rates and triple tandem mass spectrometers. The analytes targeted were small molecules most of the time and drivers for adoption were inter-related. Contrasting the majority of methods of tandem mass spectrometry-based in clinical lab, these advanced screening applications characteristically employ flow-injection without chromatographic separation. They are semi-qualitative or quantitative in nature. Low costs involved with deployment of clinical mass spectrometry significantly fuels adoption levels. However, the move to mass spectrometry is also reasoned by factors such as assay superiority. This enhancement in quality is illustrated by testosterone. Measuring testosterone was unreliable in individuals with squat endogenous concentrations such as in children and women. The greater functionality of LC-MS/MS allowed subjects from this group of individuals to be examined more consistently than before.
Increasing automation and growing demand for tissue imaging to drive growth of the overall clinical mass spectrometry market
The future of clinical mass spectrometry is quite promising. It is expected that the rising inclination toward automation eventually will result in the emergence of fully automated medical analyzers using detection techniques based on clinical mass spectrometry. At that point clinical mass spectrometry is likely to develop into a developed technology and will be widely used both by small and large clinical laboratories. In the short-term, a transitional technology of user-friendly mechanization of clinical analyzers may increase growth of the clinical mass spectrometry industry during the forecast period.
Imaging of tissue is another developing technology that uses mass spectrometry. Tissue imaging is primarily needed for examining the neural architecture in organisms. The amount of information provided by mass spectrometry is much higher than conventional stain-based histology. This would result in higher adoption of the technique thereby boosting the clinical mass spectrometry market in the near future.
Clinical Mass Spectrometry Market Taxonomy
On the basis of product type, the global market is classified into:
- LC-MS
- GC-MS
On the basis of application, the global market is classified into:
- Clinical Diagnostics
- Clinical Testing
- Proteomics
- Drug Discovery
As the complexities of diseases is on the rise, so are the number of clinical research activities aimed towards finding effective treatment of these diseases. Clinical mass spectrometry enables researchers to successfully test and hypothesize their objectives and results more accurately, at lower costs. Government initiatives for inculcation of clinical mass spectrometry, owing to low investments and better clinical outcomes will further augment growth of the overall clinical mass spectrometry market.
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