Cell line is a permanently established cell culture, which
proliferates in fresh medium. Cell line development is utilized for
examining efficiency of drug discovery and toxicity. It is essential
for the production of recombinant proteins production such as,
monoclonal antibodies, bi-specific monoclonal antibodies, growth
factors, and enzymes using a wide variety of expression systems. Cell
lines saves the crucial time, effort and cost by providing the high
yield cells which can be used for in vitro testing and reduce chance
of research drug to fail in clinical trial stage.
Development of novel therapy to drive growth of the cell line
development market
Cell line development has wide application areas. Development of
immunotherapy for the treatment of cancer is major application of
cell line development. According to the World Health Organization
factsheet 2012, cancer is one of the leading cause of death from top
three causes of non-communicable disease. Pharmaceutical and
biotechnological companies are focusing on developing novel therapies
such as immunotherapy due to its specificity and efficiency. Cell
line development helps in speeding drug discovery process and
optimization of clinical trials by providing high yield of monoclonal
antibodies, which is expected to fuel growth of the cell line
development market.
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North America to dominate the market for cell line development due
to high investment in research by pharmaceutical companies to develop
novel product
North America is expected to hold the dominant position in the global
cell line development market, owing to high investment by
pharmaceutical companies in developing a novel treatment product and
increasing off patenting of major products, which would promote
biosimilar drug development. Biosimilar drug having biological
molecule needs to match in structure and composition with original
product which needs cell line to confirm matching of structure and
adhere to quality attribute such as glycoprofile, protein
aggregation. For instance, according to 2016 report of International
Trade Administration of Department of Commerce (USA), the U.S.
generic drug sales reached an estimated US$ 70 billion in 2015, which
represents quarter of the global market, due to a large number of
drugs going off-patent and healthcare reforms favoring generics
development.
Collaborations by cell line development companies with drug
discovery companies to speed up expansion of cell line development
market
Some of the major players operating in the global cell line
development market include Lonza Group AG, Sigma-Aldrich
Corporation, Wuxi App Tec, Inc., American Type Culture Collection,
Thermo Fisher Scientific, Inc., PX’Therapeutics SA., Selexis SA, GE
Healthcare, European Collection of Cell Cultures , Corning, Inc.,
Sartorious AG, Goodwin Biotechnology Inc., and Cleancells.
Cell Line Development Market Taxonomy
On the basis of Product type:
• Reagents & Media
• Equipment
On the basis of source:
• Mammalian
• Non-Mammalian
On the basis of cell line:
• Recombinant
• Hybridomas
• Continuous Cell Line
• Primary Cell Line
On the basis of application:
• Bioproduction
• Drug Discovery
• Toxicity Testing
• Tissue Engineering
• Research
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