Next Generation Sequencing Market Gaining a Strong Foothold 2025

Next Generation Sequencing (NGS) is a high-throughput DNA sequencing technology that separates billions or millions of DNA strands and sequence in parallel, yielding more output and reducing the need for fragment-cloning methods (Sanger sequencing of genomes). However, read lengths for NGS are shorter than Sanger due to the signal to noise ratio, which increases with read length. NGS allows simultaneous screening of mutations in large number of genes. For example, a patient with symptoms of Leigh syndrome performed exome sequencing to find candidate gene variants. Furthermore, it is used for analysis and for interpreting sequenced data, analyzing specific gene associated with the patient’s clinical condition.

Market Dynamics

Major factors driving growth of the next generation sequencing market are early detection of cancer and infectious diseases and increasing partnership among academic and industry partnerships for research and development. For academic institutions, these collaborations help in commercialization of their discoveries from basic research to medical products. For instance, in March, 2018, Cofactor Genomics, a U.S.-based developer of Cofactor Paragon (RNA analysis tool) signed agreement with National Cancer Institute, and other three other pharma and academic institutes to show clinical ability of its product.

Increasing prevalence of cancer and infectious diseases and ability of NGS platforms to detect cancers and infectious diseases are expected to drive growth of the next generation sequencing market during the forecast period. The use of NSG for study of cancer cells mutations is increasing and the implementation of this technology has considerably aided in early diagnosis of diseases. In the U.S., over 1.69 million new cancer cases were detected in 2016; whereas the global incidence of cancer was around 14 million new cases in 2012 and an annual 19.3 million cases are estimated by 2025. However, interpretation of complex data, lack of skilled professionals, and issues related to security of NGS data are expected to limit growth of the market.

Increasing demand for DNA testing

Demand for DNA testing is increasing, due to advancements in whole genome and exome sequencing procedures, faster results and cost effectives of the process as compared to genotyping based DNA microarray. In December, 2014, the first commercial sequencer, MinIon, using Nanopore technology was introduced by Oxford Nanopore Technologies. The sequencer identifies DNA by measuring the changes in the electrical conductivity generated DNA strands passed through biological pore. This technology enabled the detection of outbreaks such as Zika virus. Furthermore, GenapSys, a U.S.-based developer of DNA sequencing technologies for applied genomic testing, introduced GENIUS sequencer, which can sequence DNA anywhere.

Next Generation Sequencing Market - Key players

Key players in the next generation sequencing market include Thermo Fisher Scientific Inc., Agilent Technologies, Inc., BioMerieux S.A., F. Hoffmann-La Roche Ltd, Qiagen N.V., Illumina, Inc., Oxford Nanopore Technologies, and Beijing Genomics Co. Ltd.

Detailed Segmentation:

Global Next Generation Sequencing Market, By Technology:

• Whole Genome Sequencing

• Whole Exome Sequencing

• RNA Sequencing

• Targeted Re-sequencing

• Others

Global Next Generation Sequencing Market, By Application:

• Drug Discovery

• Personalized Medicine and Genetic Screening

• Disease Diagnosis

• Agriculture and Animal Research

• Others

Global Next Generation Sequencing Market, By End User:

• Hospital

• Research Centers

• Pharma and Biotech Firms

• Others

Global Next Generation Sequencing Market, By Region:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Cryotherapy Market Present Situation and Potential Growth with Forecast Report 2024

Cryotherapy is an alternative tumor treatment option, usually preferred in cases wherein removal of tumor using conventional surgery is not effective. Cryotherapy is also utilized in treating skin disorders, for anti-aging, muscle pain and recovery, and for muscle-related injuries. Cryotherapies are broadly classified as localized/surgical cryotherapy or cryosurgery and whole-body cryotherapy. Cryosurgery is used for treatment of skin conditions, cancer, and pain. Whole body cryotherapy (WBC) find applications in health and fitness, generally performed opted for by athletes and film personalities. Liquid nitrogen cooled sauna or cryotherapy chamber (exposed to fresh oxygenated cooled air) are some of the more non-conventional techniques employed in WBC. Cryotherapy chambers are usually preferred by cryotherapy centers or at home-facilities. Cryo-guns, cryo probes and gas cylinders are mainly used in hospitals and clinics for major cryotherapy procedures.

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Market Dynamics

The global cryotherapy market growth is expected to be mainly driven by increasing incidence of cancer and high prevalence of skin disorders. According to WCRF International, 1.1 million new cases of prostate cancer among men were diagnosed in 2012. Incidence rates are especially high in Australia, New Zealand, North America, and in Western and Northern European countries.

Moreover, the global cryotherapy market is characterized by varied end users such as hospitals, cryotherapy centers, fitness centers, and specialty clinics. Use of cryotherapy as a mode of alleviating muscular pain is increasing rapidly with the advent of cryotherapy chambers. Exposure to fresh oxygenated cooled air rather than liquid nitrogen, which poses threat to life if exposed for long time, is driving attention for cryotherapy chambers among consumers intending to reduce pain by cryotherapy. Although, treatment has been beneficial in many cancer cases, more studies are required to establish safety and effectiveness as opposed to chemotherapy, surgery, and radiation therapy.

Market Major Players

Major players operating in the global cryotherapy market include CryoConcepts LP, Wallach Surgical Devices, CooperSurgical, Inc., Cryoalfa, Medtronic PLC, US Cryotherapy, Metrum Cryoflex, Brymill Cryogenic Systems, and Galil Medical, Inc.

Market Taxonomy

This report segments the global cryotherapy market on the basis of product type, application, therapy type, end user, and geography. On the basis of product type, the global cryotherapy market is categorized into cryo-gun, cryo probes, gas cylinders, and others. On the basis of application, the market is segmented into oncology, cardiology, dermatology, pain management, and others. On the basis of therapy type, the global cryotherapy market is segmented into cryosurgery, ice-pack and cryo chamber therapy. The end user segment is divided into hospitals, fitness centers, specialty clinics and cryotherapy centers. For comprehensive understanding of market dynamics, the global cryotherapy market is analyzed across key geographical regions namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

Detailed Segmentation:

Global Cryotherapy Market, By Product Type:

• Cryogun

• Cryo Probes

• Gas Cylinders

• Others (Cryochambers, thermocouple device, etc.)

Global Cryotherapy Market, By Application:

• Oncology

• Cardiology

• Dermatology

• Pain Management

• Other

Global Cryotherapy Market, By End User:

• Hospitals

• Specialty Clinics

• Fitness centers

• Cryotherapy centers

Global Cryotherapy Market, By Geography:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Monoclonal Antibody Therapeutics Market to Surpass US$ 174.2 Billion Threshold by 2026

Monoclonal antibodies Robust pipeline, success of monoclonal antibodies such as Humira (AbbVie, Inc.) and therapeutic advantages offered by these drugs over existing medications are expected to boost growth of the global monoclonal antibody therapeutics market. Moreover, key players in the market are focused on research and development of new monoclonal antibodies in order to enhance their market share.

For instance, in 2017, the U.S. Food and Drug Administration (FDA) granted accelerated approval to avelumab (BAVENCIO, EMD Serono, Inc.) for the treatment of a rare disease, Metastatic Merkel Cell Carcinoma (MCC). Similarly, in 2017, the U.S FDA granted accelerated approval to immunotherapy product- TECENTRIQ (atezolizumab) for the treatment of people with locally-advanced or metastatic urothelial carcinoma (mUC). In 2015, Sanofi and Regeneron Pharmaceuticals, Inc. entered into a strategic collaboration to develop and commercialize new antibody cancer treatment (SAR439684) in the oncology market. Sanofi and Regeneron are developing an antibody-based cancer therapy- REGN2810 (SAR439684) for the treatment of cutaneous squamous cell carcinoma, which is currently in phase 2 clinical trials.

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Increasing product launches and regulatory support for the treatment of rare diseases is expected to support growth of the monoclonal antibody therapeutics market. Several companies have received the U.S FDA approvals for drugs used in treatment of diseases ranging from cancers to rare diseases. For instance, in August 2018, Kyowa Hakko Kirin Co., Ltd received the U.S. FDA approval for Poteligeo (mogamulizumab-kpkc) for the treatment of adult patients with relapsed or refractory mycosis fungoides (MF) or Sézary syndrome (SS) after at least one prior systemic therapy. Moreover, in August 2018, Shire plc. received the U.S. FDA approval for TAKHZYRO (lanadelumab-flyo) injection for a rare disease hereditary angioedema (HAE) in patients 12 years of age and older. Increasing focus of key players for developing monoclonal antibodies for various cancers and rare diseases is expected to boost the global monoclonal antibody therapeutics market growth over the forecast period.

Monoclonal antibody therapeutics market is driven by active research and development of novel drugs and significant number of new drug launches and approval. There are number of monoclonal antibodies in the pipeline, which are expected to receive approval over the forecast period. For instance, manufacturers such as Amgen, Inc., Novartis International AG, Merck & Co., Inc., Eily, Lilly, and Company, and others have several monoclonal antibodies in the pipeline. Moreover, efforts of manufacturers to increase number of indications (oncology) for monoclonal antibodies is further expected to boost the market growth over the forecast period. For instance, in June 2018, the U.S. Food & Drug Administration (FDA), expanded the indication of pembrolizumab (Keytruda) to include recurrent or metastatic cervical cancer with disease progression on or after chemotherapy.

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Some of the major players operating in the global monoclonal antibody therapeutics market include, Pfizer, Inc., Novartis International AG, Amgen, Inc., Sanofi S.A., Merck & Co., Inc., GlaxoSmithKline Plc., F. Hoffmann-La Roche Ltd., AbbVie, Inc., Eily, Lilly, and Company, and Bristol-Myers Squibb Company.

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CAR T Cell Therapy Market

The Global #CarT #Cell #Therapy #Market is expected to be valued at US$ 7.7 Billion by 2028, as analyzed by Coherent Market Insights​. Increasing demand for genetically engineered #treatment approach for high success rate in #cancer #treatment along with growing cancer incidence rate are key factors driving demand for CAR T cell therapy products #worldwide.

Key players operating in the global CAR-T cell therapy market include Novartis International AG, Kite Pharma, Inc. (Gilead Sciences, Inc.), Juno Therapeutics (Celgene Corporation), Bluebird Bio, Inc. (Celgene Corporation), Sorrento Therapeutics Inc., Mustang Bio, Inc., Aurora Biopharma Inc., Legend Biotech (Genscript Biotech Corporation), Pfizer, Inc., CARsgen Therapeutics, Ltd., and others.

Automatic Stair Climbing Wheelchair Market - Industry Growth, Outlook, and Trends By 2018–2026

Automatic stair climbing wheelchair is designed for individuals having limited lower extremity mobility conditions associated with spinal cord injuries, stroke, traumatic brain injury or multiple sclerosis. This wheelchairs allow the user to move in a variety of positions such as reclining, standing, being lowered to the ground, and being elevated. Stair climbing wheelchair are categorized into continuous, intermittent, and auxillary. Electric-powered wheelchair with stair-climbing ability is major requirement for many of the patients and elderly people suffering from walking dysfunction.

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Automatic Stair Climbing Wheelchair Market Driver

Increasing initiatives by the major players to develop innovative products is expected to fuel automatic stair climbing wheelchair market growth. For instance, in 2017, a team in Zurich introduced the Scewo. Scewo is self-balancing stair climbing wheelchair that can go up and down stairs independently and smoothly and provides features useful for navigating over obstacles. By using multiple rubber tracks, it can provide smooth and safe ride on the stairs. Furthermore, in 2015, a team in Zurich launched the Scalevo, the original prototype consist of two big wheels with a Segway-styled balancing system to navigate flat ground.

However, high cost of the automatic stair climbing wheelchairs is expected to hamper the market growth. For instance, in 2003, the subsidiary firm by Johnson Company in USA developed IBOT, a stair climbing wheelchair. The price of IBOT was so high that most of people could not afford it and it was discontinued in 2009.

Automatic Stair Climbing Wheelchair Market Regional Analysis

On the basis of region, the global automatic stair climbing wheelchair market is segmented into North America, Latin America, Europe, Asia Pacific, Middle East, and Africa.

Geographically, North America region is expected to hold the largest market share for automatic stair climbing wheelchair market, owing to rising number of people with disabilities in the US. For instance, in 2016, American Community Survey (ACS), estimated that rate of people with disabilities in the U.S. population was 12.8%. The percentage of people with a disability has increased from 11.9% in 2010, to 12.8% in 2016.

Moreover, Asia Pacific is anticipated to witness significant growth in automatic stair climbing wheelchair market attributed to presence of major players in this region. For instance, in May 2016, Toyota, the automobile company, joined Kamen's company DEKA, to support mobility solutions for the disabled community. This agreement was made to develop and launch the next generation of the IBOT. The IBOT motorized wheelchair was launched back in 2001, by Segway inventor Dean Kamen. However, the price of IBOT was US$ 25,000 which was too expensive for the mainstream market resulting into discontinuation of device in 2009.

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Key players for automatic stair climbing wheelchair market include TopChair, B-Free Technology Limited, Toyota, designboom, Vin Grace Solutions (P) Ltd., and Johnson and Johnson.

Automatic Stair Climbing Wheelchair Market Taxonomy,,By Mode of Operation,,Manual,Powered,By End User,,Hospitals,Rehabilitation Centers,Home Care Settings,Others,By Region,,North America,Europe,Asia Pacific,Latin America,Middle East,Africa

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Veterinary Vaccines Market Is Progressing Towards A Strong Growth By 2024

Veterinary/Animal vaccines are parenteral products that are used as prophylactic as well as in treatment of various veterinary diseases. Veterinary vaccines play a crucial role in ensuring good health, longevity, and improving overall productivity of pets and livestock, in a cost-effective manner. It also plays an extremely important role in curtailing incidence of transmission of various diseases from animals to humans. Vaccines are broadly classified as inactivated vaccines, toxoid vaccines, live attenuated vaccines, conjugated vaccines, subunit and DNA vaccines. Inactivated vaccines are considered as safe vaccines, though they contain extraneous proteins or adjuvants, which can increase risk for development of acute vaccine reactions. Veterinary vaccines impact animal health and production quality and also help ensure good health of general human population through consumption of various food procured from animals. The continued interaction between animals and health professionals are the major importance for adaption of novel technologies in heath sector by providing animal models of disease.

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Market Dynamics:

Rapid increase in population of companion animals and livestock animals globally is one of the major factors expected to favor market growth for veterinary vaccines. Rise in awareness about the vaccination programs are further favoring growth of the global veterinary vaccines market. The market is estimated to witness considerable revenue traction over the forecast period, due to increasing incidence of food-borne zoonotic diseases worldwide. Also, rise in demand for white meat in the North American and European countries is in turn expected to support growth of the veterinary vaccines market in the near future. According to the PoultrySite - Poultry News, Health, Welfare, Diseases, Markets and Economics, in 2013, there was a significant rise in demand for white meat in Italy since a decade, with demand for turkey, chicken and eggs increased by 8.5%, while production of poultry increased by 16%.

Market Taxonomy:

This report segments the global veterinary vaccines market on the basis of technology, animal type and geography. On the basis of product type, the market is categorized into inactivated vaccines, toxoid vaccines, live attenuated vaccines, conjugated vaccines, subunit and DNA vaccines. On the basis of animal type, the market is segmented into companion animal and livestock animal. The companion animal type segment is sub-segmented into equine, canine, and feline. The livestock animal type segment is further sub-segmented into bovine, ovine, porcine, poultry and other animals. For comprehensive understanding of market dynamics, the global veterinary vaccines market is analyzed across key geographical regions namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

Key companies covered as a part of this study include,

Zoetis Inc. Merck Animal Health, Merial Inc. , Boehringer Ingelheim , Bayer Animal Health, Elanco Animal Health, Ceva Animal Health, Heska Corporation, Virbac Inc., and Indian Immunological Ltd.

Detailed Segmentation:

Global Veterinary Vaccines Market, By Technology Type:

• Inactivated Vaccines

• Toxoid Vaccines

• Live Attenuated Vaccines

• Subunit and DNA Vaccines

• Conjugated Vaccines

Global Veterinary Vaccines Market, By Animal Type:

• Companion Animal

• Equine

• Canine

• Feline

• Livestock Animal

• Bovine

• Ovine

• Porcine

• Poultry

• Others

Global Veterinary Vaccines Market, By Geography:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Automated Breast Ultrasound Systems (ABUS) Market

Dermatology Devices Market to Register Steady Expansion By 2024

Until about a decade ago, skin diseases were not considered to be much of a concern among the medical fraternity, with focus mainly towards combating major diseases such as HIV/AIDS and hospital-acquired pneumonias. However, in primary care settings, skin disorders are the common diseases prevalent in tropical areas. HIV infection related skin diseases are especially common in sub-Saharan geographies. In 2015, according to Turkish Journal of Family Medicine & Primary Care, infections related to skin are common worldwide with a prevalence of pyoderma between 0.2% and 35%, for tinea capitis it is around 19.7%, for scabies it ranges between 0.2% and 24%, and for viral skin disorders it ranges between 0.4% and 9%.

Market Dynamics

Rise in number of skin infections and rise in demand for skin rejuvenation is expected to propel growth of the dermatology disease market. Rise in demand for skin rejuvenation therapy is backed up by increasing use of radiofrequency techniques, which in turn is expected to favor the market for dermatology devices market in the near future. Furthermore, high prevalence of skin mycoses globally is projected to have a positive effect on the growth for dermatology devices market. According to article published in 2008 by John Wiley & Sons, Inc., high prevalence of skin mycoses was around 20–25% and thus, was considered as one of the most prevalent forms of infection worldwide. The last decade has witnessed a spurt in incidence of skin diseases caused by pathogens such as anthropophilic and zoophilic dermatophytesm, which are especially prevalent in regions tropical regions due to the favorable growth environment. Also, change in lifestyle and awareness about the treatment is also one of the major factor affecting positively the growth of dermatology devices market. Scar and tattoo removal are some of the examples that require dermatology devices. According to Deccan Chronicles, in 2016, there were 25,000 tattoo removal cases recorded in India of the 128,218 cases worldwide, as revealed by a survey conducted by the International Society of Aesthetic Plastic Surgery (ISAPS) in 2015.

Advancement in technology is expected to be a threat for conventional treatment methods in the dermatology devices market

The treatment procedures that are minimally invasive are gaining attention in the medical community and among patients, worldwide. Therefore, there is a high demand for devices such as microdermabrasion, pens for pigmented lesions, scars, and loose skin, and laser therapy globally. The conventional surgical procedures used for the treatment of skin disorders are replaced with these devices, as conventional procedures leaves out unwanted scars post-surgery. Some of the safe and effective treatment options for acne scarring include laser resurfacing, dermabrasion, and chemical peels. Researches based on the effectiveness of laser and light therapies in treating mild to moderate acne is still going on.

PMD Beauty pioneered the at-home microdermabrasion device that allows users to perform microdermabrasion procedure at ease and convenient. The device has a large consumer base in the U.S., U.K. and Australia.

Market Taxonomy

This report segments the global dermatology devices market on the basis of product type, application, end user, and geography. On the basis of product type, the market is categorized into microdermabrasion devices, lasers and others. The laser product type segment is sub-segmented into alexandrite laser, diode, fractional, infrared 1319 nm, nd:yag 1064 nm, potassium titanyl phosphate (ktp), pulsed. The application segment is divided into vascular lesions, scar removal, tattoo removal, hair removal, wrinkle removal, acne treatment, skin rejuvenation, pore reduction and others. The vascular lesions application segment is further divided into telangiectasia, hemangiomas, port wine stains and venous lakes and scar removal application segment is sub-divided into red or hypertrophic scars and hyper-pigmentation. For comprehensive understanding of market dynamics, the global dermatology market is analyzed across key geographical regions namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

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Market Players

This is expected to benefit the dermatology devices market players such as Valeant Pharmaceuticals International Inc., Lumenis, Ltd., Cynosure Inc., Syneron Candela Ltd., Avita Medical Ltd., Alma Lasers, Ltd., Lutronics Corporation, Beijing Toplaser Technology Co. Ltd., Shanghai Fosun Pharmaceutical Group Co. Ltd., and Cutera, Inc.

Detailed Segmentation:

Global Dermatology Devices Market, By Product Type:

• Microdermabrasion Devices

• RF Devices

• Lasers

- Alexandrite laser

- Diode

- Fractional

- InfraRed 1319 nm

- Nd:YAG 1064 nm

- Potassium Titanyl Phosphate (KTP)

- Pulsed

• Others

Global Dermatology Devices Market, By Application:

• Vascular Lesions

- Telangiectasia

- Hemangiomas

- Port wine stains

- Venous lakes

• Scar Removal

- Red or hypertrophic scars

- Hyperpigmentation

• Tattoo removal

• Hair removal

• Wrinkle Removal

• Acne Treatment

• Skin Rejuvenation

• Pore Reduction

• Others

Global Dermatology Devices Market, By End User:

• Hospitals

• Specialty Dermatology Clinics

• Private Clinics

Global Dermatology Devices Market, By Geography:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Sinus Dilation Devices Market to Surpass US$ 5.7 Billion by 2026

Global Sinus Dilation Devices Market, by Product Type (Balloon Sinuplasty Systems Rhinoscopes, Sinuscopes, Sinus Stents, Functional Endoscopic Sinus Surgery (FESS) Instruments Set, and Others), by End User (Hospitals & Clinics and Ambulatory Surgical Centers (ASCs)), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) was valued at US$ 2.7 Billion in 2017, and is projected to exhibit a CAGR of 8.4% over the forecast period (2018 – 2026), as highlighted in a new report published by Coherent Market Insights.

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Sinusitis is an inflammation of sinus, which causes nose blockage and avoids mucus drainage. Sinus dilation devices are used in patients with nose drainage issues related to nasal sinusitis or sinuses to expand the sinus openings. Different types of sinus dilation devices includes balloon sinuplasty systems, rhinoscopes, sinus stents, and functional endoscopic sinus surgery (FESS), and instruments set for sinuses or sinusitis

New launches of sinus dilation devices by market players augment growth of the market

Key players in the market are focused on launching novel catheters in order to reduce nasal sinusitis or sinuses and address the critical unmet needs of patients. For instance, in January 2014, Acclarent Inc. launched a new range of Balloon Sinuplasty System, RELIEVA, in the U.S. for the treatment of chronic sinusitis in children. This will help the company to diverge its portfolio for various age groups.

Similarly, in June 2015, SinuSys Corporation received CE mark for its two new devices to treat frontal and sphenoid sinusitis, in addition to maxillary disease. This will help the company to expand its product portfolio of low-pressure and self-expanding dilation devices.

Browse 36 Market Data Tables and 32 Figures spread through 164 Pages and in-depth TOC on ‘Sinus Dilation Devices Market’- Global Forecast to 2026, by Product Type (Balloon Sinuplasty Systems Rhinoscopes, Sinuscopes, Sinus Stents, Functional Endoscopic Sinus Surgery (FESS) Instruments Set, Others), by End User (Hospitals & Clinics, Ambulatory Surgical Centers (ASCs)), and by Region (North America, Latin America, Europe, Asia Pacific, Middle East, and Africa) To

Key players are focusing on adopting various business strategies such as mergers and acquisitions to enhance its product portfolio. For instance, Stryker Corporation completed the acquisition of Entellus Medical Inc. in February 2018. Through this acquisition, Stryker Corporation would promote products of Entellus Medical Inc.

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Key Takeaways of the Sinus Dilation Devices Market:

The global sinus dilation devices market is expected to exhibit a CAGR of 8.56% over the forecast period, owing to increasing prevalence of chronic sinusitis

Among product type, the balloon sinuplasty systems segment held a dominant position in the sinus dilation devices market in 2017 owing to higher adoption rate for sinusitis treatment.

Among end user, hospitals and clinics segment held a dominant position in the sinus dilation devices in 2018. This is attributed to the fact that the number of patients visiting hospital and clinical settings is higher as compared to ambulatory surgical centers.

Key players operating in the global sinus dilation devices market include, Entellus Medical, Inc., Smith & Nephew Plc., Acclarent, Inc., B. Braun Melsungen AG, Medtronic Plc, Olympus Corporation, SinuSys Corporation, InnAccel Technologies, Intersect ENT, Inc.

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Companion Diagnostics Market Breaking Down Into Type, Application And Regions 2018-2026

Companion diagnostic (CDx) is a diagnostic tool used to determine the suitability of a drug therapy to the patient. It has become a critical part of targeted cancer therapy that allows for development of personalized therapy can be developed and administered to the patient. Whole blood samples, tissues samples, or buccal samples are collected and tested for diagnosis and identification of targeted disease biomarker. CDx is usually utilized in identifying genetic mutations and the health and treatment approach implications. In July 2016, the U.S. FDA released a draft guideline for development of a therapeutic product accompanying an IVD companion diagnostic. Companion diagnostics include Gleevec (imatinib mesylate) and BCR-ABL LDT and DAKO C-KIT PharmDx, Herceptin (trastuzumab) and DAKO Herceptest; and Nolvaldex (tamoxifen) and laboratory-developed estrogen receptor positive test.

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Market Dynamics

Companion diagnostics are beneficial for pharmaceutical companies who face challenges with respect to high drug development cost, safety and outcome of clinical trials, and long product approval time. Companion diagnostics lowers development costs, improves time to market and enhances drug safety by enabling rapid identification of target biomarker and the most effective drug therapy. For patients, the technology provides better treatment outcomes and lower morbidity risk. Use of technologies such as PCR, immunohistochemistry, and gene sequencing has enabled accurate diagnosis and determination of targeted cancer therapy. As the CDx tests also aid in revealing the off-target effects of a drug along with identification of a molecular target, CDx have become and indispensable tool for oncologists.

Research collaborations to improve the time to market the product

An integrated and more evidence-based approach is driving partnerships in the global companion diagnostics market. According to Wildwood Ventures Ltd., the number of global deal in companion diagnostics market has increased from 13 in 2007 to 66 in 2013. Since, developing CDx test along with drug therapy is a capital intensive and complex process, industry players are collaborating to leverage on each other’s expertise. For instance:

• Invivoscribe Technologies Inc., collaborated with Novartis AG and Astellas Pharma Inc. to develop companion diagnostics for their drugs under pipeline.

• Invivoscribe also announced a long-term partnership with Thermo Fisher Scientific in January 2017, develop and commercialize IVD assays for Applied Biosystems® 3500 Dx Series Genetic Analyzers. Invivoscribe Technologies Inc. is a global company engaged in providing clonality and biomarker test solutions for oncology and personalized molecular diagnostics.

• AstraZeneca plc entered into a deal with Abbott Laboratories, Inc. in 2015, to develop a companion diagnostic test for tralokinumab, used for treating severe asthma.

• Singulex, Inc. entered into a strategic collaboration with QIAGEN N.V. in January 2017 to develop companion diagnostics using Singulex's proprietary Single Molecule Counting (SMC) immunodiagnostic platform

Increasing number of research collaborations is expected to improve the time to market of highly effective targeted drug therapies. This would in-turn augment the growth of companion diagnostics market.

Market Taxonomy

This report segments the global companion diagnostics market on the basis of application, technology, and geography. On the basis of application, the market is categorized into breast cancer, lung cancer, colorectal cancer, gastric cancer, melanoma, and others. On the basis of technology, the market is segmented into immunohistochemistry, real-time PCR, gene sequencing, Fluorescence in situ hybridization (FISH), and others. For comprehensive understanding of market dynamics, the global companion diagnostics market is analyzed across key geographical regions namely North America, Europe, Asia Pacific, Latin America, Africa, and Middle East. Each of these regions is analyzed on basis of market findings across major countries in these regions for a macro-level understanding of the market.

Detailed Segmentation:

Global Companion Diagnostics Market, By Application:

• Breast Cancer

• Lung Cancer

• Colorectal Cancer

• Gastric Cancer

• Melanoma

• Others

Global Companion Diagnostics Market, By Technology:

• Immunohistochemistry

• Real-time PCR

• Gene Sequencing

• FISH

• Others

Global Companion Diagnostics Market, By Geography:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Dental Equipment Market Are Made : An Overview To The Future Opportunities Over The Global

Practice of dentists has shifted from being focused on disease treatment to preventive measures. This change in market dynamics is acting as a catalyst for development of new technologies for diagnosis and treatment of dental issues Growing awareness about dental care among consumers has translated into rising number of routine-check-ups and growing spending on maintaining oral health. This is in turn spurring demand for dental care equipment, including dental lasers, imaging systems, and computer-aided design and computer-aided manufacturing (CAD/CAM) systems.

Market Dynamics

Dental equipment finds extensive application in diagnosis and treatment of dental disorders such as dental cavities, gingival disease, and periodontal (gum) disease. Advent of 3D printing in dental industry creates a highly favorable environment conducive for market growth and helps dentists provide better services through use of highly efficient diagnostic and treatment tools. Moreover, growing public awareness about dental treatment options, coupled with increasing expenditure on dental care is driving patients to opt for preventive measures. According to a study published in the American Dental Association’s research paper of 2014, around 52.3% of adults in the U.S. visited a dentist every six months. Focus on enhancing patient’s experience through high-quality treatment outcomes is driving demand for dental equipment worldwide.

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Development of CAD/CAM & 3D printing is expected to drive dental equipment market growth

Incision during surgeries can be carried out precisely by using laser and electro surgery techniques. This will reduce the damage caused to tissues and will aid in faster healing. The time taken for prosthodontic restoration procedures has reduced to one day due to the development of CAD/CAM. By replacing conventional radiology equipment with digital radiology equipment equipped with picture archiving and communication systems (PACS), treatment records can be archived. Moreover, outcomes of dental treatments have improved due to 3D printing technology. When compared to the conventional CT systems, cone beam CT systems provides clear extra oral images and exposure to harmful X-rays will be minimal.

Increasing preference for refurbished dental equipment impacting the growth of overall dental equipment market

Budget constraints in emerging countries such as India, China, Brazil and Eastern European countries is driving demand for refurbished dental equipment. This aids the newly established dental clinics and laboratories to achieve cost-efficiency with quality throughput. New dental equipment such as cone beam CT systems, vacuums & compressors, cad/cam, digital X-ray units and laboratory equipment involve high capital investment. This may increase the cost of patient dental procedures, thus negatively impacting the number of patient visits. Therefore, most dentists and hospitals in emerging countries prefer refurbished equipment, which in turn helps them pass on the cost-saving benefits to their patients. Market players such as Danaher Corporation, Planmeca Oy, and Dentsply Sirona, Inc. must consider the cost parameters while targeting the cost-sensitive customer base in emerging countries that are projected to be highly lucrative dental equipment markets in the near future.

Market Taxonomy

This report segments the global dental equipment market on the basis of equipment type and end user. On the basis of equipment type, the market is classified as dental imaging equipment, dental lasers, dental laboratory equipment, hygiene maintenance devices, systems and parts, and others. End users of these equipment are hospitals, dental clinics, and dental laboratories.

Global Key Players

A-Dec Inc., 3M ESPE, Carestream Heath, Inc., Biolase Inc., Noble Biocare, Danaher Corporation, Ivoclar Vivadent AG, Dentsply Sirona, Inc., Henry Schein, Inc., Patterson Companies Inc., Planmeca Oy, and Institut Straumann AG.

Detailed Segmentation:

Global Dental Equipment Market, By Equipment Type:

• Dental imaging equipment

• Dental lasers

• Dental laboratory equipment

• Hygiene maintenance devices

• Systems and parts

• Other dental equipment

Global Dental Equipment Market, By End User:

• Hospitals

• Dental clinics

• Dental laboratories

Global Dental Equipment Market, By Geography:

• North America

• Latin America

• Europe

• Asia Pacific

• Middle East

• Africa

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Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.

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Artificial Pancreas Device System (APDS) – Putting the Ease in Diabetes Management

The Global Artificial Pancreas Device System (APDS) Market was valued at US$ 64.0 million in 2015 and is projected to expand at a CAGR of 18.6 % during the forecast period (2016–2024), as highlighted in a new report published by Coherent Market Insights. Growing demand for continuous diabetes monitoring and minimally invasive drug delivery system is expected to fuel growth of the artificial pancreas device system (APDS) market.

Type 1 diabetes patients require multiple doses of insulin through the day in order to manage their diabetes condition. Considering the current lack of feasible alternative solution to manage type 1 diabetes apart from administering insulin, an artificial pancreas that offers convenience with continuous management of glucose level in the body is the next best solution. An artificial pancreas system works 24 hours to automatically monitor and administer insulin in controlled amounts as per variations in glucose levels in the body. Medtronic’s MiniMed 620G and 640G were the first such devices launched in the global artificial pancreas device system (APDS) market in 2014 and 2015, respectively. Artificial pancreas system would ease the life of type 1 diabetic patients by eliminating the need for regular check on glucose level and administering insulin using injectors or pens.

To know the latest trends and insights prevalent in the artificial pancreas device system (APDS) market, click the link below:

https://www.coherentmarketinsights.com/market-insight/artificial-pancreas-market-79

Market players are majorly investing in research activities for development of artificial pancreas system in order to introduce novel treatment option in the market. For instance, Bigfoot Medical, Tandem Diabetes Care, Inc., and Beta Bionics are conducting clinical trials on artificial pancreas systems. The products are expected to be launched before 2020, which is expected to drive growth of the market. Furthermore, Medtronic’s 640G, Medtrum’s P6 Easy Touch Disposable Pump marketed in Europe is a semi-closed loop artificial pancreas that has 9% mean absolute relative difference (MARD), better than Freestyle Libre (11.4% MARD)

The closed loop system is majorly used for treatment of patients suffering from type 1 diabetes. Although. FDA has approved a hybrid model of an artificial pancreas, wherein the patient needs to adjust insulin intake during mealtime, an automated system would be a breakthrough innovation in the global artificial pancreas device system (APDS) market. Moreover, studies for bi-hormonal control system are in progress, which would enable controlling both hypoglycemic and hyperglycemic conditions. A bi-hormonal control system consists of dual-chamber pump, one containing insulin and the other containing counteracting hormone, glucagon.

According to the industry and Center for Diseases Control and Prevention (CDC) estimates, type 1 diabetes population accounts for nearly 5% of the total diabetic population. According to Juvenile Diabetes Research Foundation (JDRF), around 1.5 million type 1 diabetic patients were reported worldwide in 2015. The CDC estimates that more than 13,000 young people are diagnosed with type 1 diabetes annually in the U.S. Increasing number of population base along with the quest for developing an innovative diabetes monitoring and management therapy is projected to drive growth of the global artificial pancreas device system (APDS) market.

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Key takeaways of the market:

• The global artificial pancreas device system (APDS) market is characterized by collaborations between players in order allow for early commercial launch of their products. Moreover, a number of products are in development with different artificial pancreas system technologies. However, an automated hybrid closed-loop system would dominate the market owing to better features offering convenience and minimal monitoring and work for the patient to administer insulin.
• The global artificial pancreas device system (APDS) market is expected to experience very high growth during the forecast period with expected launch of new systems every year till 2020, after which it is expected to register sustained stable growth
• The market for control to target (CTT) artificial pancreas system is expected to grow rapidly with the launch of MiniMed 670G, which will eliminate the need for setting insulin dose by the patient at meal times
• Type 2 diabetic patents hold more than 95% share in the global artificial pancreas device system (APDS) market
• Furthermore, being a novel device, the market for artificial pancreas system is estimated to be high and rapidly growing in North America and Europe as these are the major target markets for market players. Launch of artificial pancreas system later in emerging economies is expected to stimulate growth in Asia Pacific and Latin America artificial pancreas device system (APDS) markets towards the latter half of the forecast period.
• Medtronic is expected to account for a major share of the global artificial pancreas device system (APDS) market, with a range of products such as MiniMed 530G, 640G, and 670G expected to be launched during the forecast period

About Coherent Market Insights:

Coherent Market Insights is a prominent market research and consulting firm offering action-ready syndicated research reports, custom market analysis, consulting services, and competitive analysis through various recommendations related to emerging market trends, technologies, and potential absolute dollar opportunity.