Next
Generation Sequencing (NGS) is a high-throughput DNA sequencing
technology that separates billions or millions of DNA strands and
sequence in parallel, yielding more output and reducing the need for
fragment-cloning methods (Sanger sequencing of genomes). However,
read lengths for NGS are shorter than Sanger due to the signal to
noise ratio, which increases with read length. NGS allows
simultaneous screening of mutations in large number of genes. For
example, a patient with symptoms of Leigh syndrome performed exome
sequencing to find candidate gene variants. Furthermore, it is used
for analysis and for interpreting sequenced data, analyzing specific
gene associated with the patient’s clinical condition.
Market
Dynamics
Major
factors driving growth of the next
generation sequencing market are early detection of
cancer and infectious diseases and increasing partnership among
academic and industry partnerships for research and development. For
academic institutions, these collaborations help in commercialization
of their discoveries from basic research to medical products. For
instance, in March, 2018, Cofactor Genomics, a U.S.-based developer
of Cofactor Paragon (RNA analysis tool) signed agreement with
National Cancer Institute, and other three other pharma and academic
institutes to show clinical ability of its product.
Increasing
prevalence of cancer and infectious diseases and ability of NGS
platforms to detect cancers and infectious diseases are expected to
drive growth of the next generation sequencing market during the
forecast period. The use of NSG for study of cancer cells mutations
is increasing and the implementation of this technology has
considerably aided in early diagnosis of diseases. In the U.S., over
1.69 million new cancer cases were detected in 2016; whereas the
global incidence of cancer was around 14 million new cases in 2012
and an annual 19.3 million cases are estimated by 2025. However,
interpretation of complex data, lack of skilled professionals, and
issues related to security of NGS data are expected to limit growth
of the market.
Increasing
demand for DNA testing
Demand
for DNA testing is increasing, due to advancements in whole genome
and exome sequencing procedures, faster results and cost effectives
of the process as compared to genotyping based DNA microarray. In
December, 2014, the first commercial sequencer, MinIon, using
Nanopore technology was introduced by Oxford Nanopore Technologies.
The sequencer identifies DNA by measuring the changes in the
electrical conductivity generated DNA strands passed through
biological pore. This technology enabled the detection of outbreaks
such as Zika virus. Furthermore, GenapSys, a U.S.-based developer of
DNA sequencing technologies for applied genomic testing, introduced
GENIUS sequencer, which can sequence DNA anywhere.
Next
Generation Sequencing Market - Key players
Key
players in the next generation sequencing market include Thermo
Fisher Scientific Inc., Agilent Technologies, Inc., BioMerieux S.A.,
F. Hoffmann-La Roche Ltd, Qiagen N.V., Illumina, Inc., Oxford
Nanopore Technologies, and Beijing Genomics Co. Ltd.
Detailed
Segmentation:
Global
Next Generation Sequencing Market, By Technology:
•
Whole Genome Sequencing
•
Whole Exome Sequencing
•
RNA Sequencing
•
Targeted Re-sequencing
•
Others
Global
Next Generation Sequencing Market, By Application:
•
Drug Discovery
•
Personalized Medicine and Genetic Screening
•
Disease Diagnosis
•
Agriculture and Animal Research
•
Others
Global
Next Generation Sequencing Market, By End User:
•
Hospital
•
Research Centers
•
Pharma and Biotech Firms
•
Others
Global
Next Generation Sequencing Market, By Region:
•
North America
•
Latin America
•
Europe
•
Asia Pacific
•
Middle East
•
Africa
Else
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