Ursodeoxycholic
acid (UDCA) is a bile acid taken as either a tablet or liquid to
treat gallstones and to treat and prevent progression of cystic
fibrosis-related liver disorders. UDCA modifies the bile acid pool by
decreasing levels of hydrophobic bile acids while increasing
proportion of nontoxic hydrophilic bile acids. UDCA can delay
development of gastroesophageal varices and progression to cirrhosis.
Moreover, it can improve long-term survival in patients with primary
biliary cirrhosis.
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Significant
improvement in liver health can be achieved through UDCA therapy in
patients with intrahepatic cholestasis of pregnancy, primary
sclerosing cholangitis, nonalcoholic fatty liver disease, cystic
fibrosis-associated liver disease, total parenteral nutrition-induced
cholestasis, graft related liver disease, and in some pediatric
cholestatic liver diseases.
The
global ursodeoxycholic acid market size was valued at US$ 457.3
million in 2017 and is expected to exhibit a CAGR of 10.1% over the
forecast period (2018 – 2026).
Increasing
prevalence of gall stones and cystic fibrosis to propel the
ursodeoxycholic acid market growth
Ursodeoxycholic
acid is being increasingly used for treatment of chronic cholestatic
liver diseases. Increasing prevalence of cystic fibrosis and gall
stones is the major factor driving growth of the global
ursodeoxycholic acid market during the forecast period. According to
the Cystic Fibrosis Foundation 2015 data, around 30,000 people
suffered from cystic fibrosis in the U.S. Moreover, around 1,000 new
cases of cystic fibrosis are diagnosed in the country, annually.
According to the American Gastroenterological Association 2017
report, gallstones is affecting 10-15% of the U.S. population
annually, which accounts for around 25 million people.
Increasing
research studies on ursodeoxycholic acid to bolster the market growth
Increasing
research studies conducted on application of ursodeoxycholic acid
(UDCA) in other disease indications is expected to fuel growth of the
global ursodeoxycholic acid market. According to the University of
Sheffield August 2018 study, UDCA improves mitochondrial dysfunction,
which is known to be a causative factor for both sporadic and
familial Alzheimer’s disease.
According
to the Cure Parkinson’s Trust, U.K. 2018 article, researchers
demonstrated that UDCA could protect dopamine cells grown in culture
from apoptosis, or programmed cell death, by regulating a specific
cell survival pathway.
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Key
Players
Major
players operating in the global ursodeoxycholic acid market include
Dipharma Francis Srl, ERREGIERRE S.p.A., Grindeks, Industria Chimica
Emiliana, Mitsubishi Tanabe Pharma Corporation, Zhongshan Belling
Biotechnology Co., Glenmark Pharmaceutical Limited, Abil Chempharma
Private Limited, Biotavia Labs Pvt Ltd, Daewoong Bio Inc., PharmaZell
GmbH, and Suzhou Tianlu Bio-pharmaceutical Co., Ltd.
Detailed
Segmentation:
Global
Ursodeoxycholic Acid Market, By Dosage Form:
-
Solid Dosage Form
-
Liquid Dosage Form
Global
Ursodeoxycholic Acid Market, By Mode of Extraction:
-
Synthetic
-
Biological
Global
Ursodeoxycholic Acid Market, By Application:
-
Gallstones
-
Cystic Fibrosis
-
Liver Cirrhosis
-
Others
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