Polymer-drug
Conjugates Market, by Product Type (PEG-a-interferon 2b, 1
PEG-L-asparaginase, and PEG-GCSF), by Application (Cancers, Hepatitis, and
Others), and by Region (North America, Europe, Asia Pacific, Latin America,
Middle East, and Africa) - Size, Share, Outlook, and Opportunity Analysis 2018
– 2026
Polymer-drug conjugates are
nano-sized drug products currently used for treating cancer and hepatitis. Polymers
are now being synthesized to be sensitive to specific enzymes that are apparent
in diseased tissue. Conventional polymers are used in polymer-drug conjugates
such as cellulose and chitin can be degraded through enzymatic activity and
acidity. The drugs remain attached to the polymer and are not activated until
the enzymes associated with the diseased tissue are present. This process
significantly minimizes damage to healthy tissues.
Polymer-drug Conjugates Market
Driver
New pipeline drugs developed
using polymer-drug conjugation are expected to propel growth of the
polymer-drug conjugates market. For instance, in march 2016, National Cancer
Institute (NCI) started undergoing phase II clinical study for CRLX101, a
nanoparticle drug conjugate composed of 20(S)-Camptothecin conjugated to a
linear, cyclodextrin-polyethylene glycol-based polymer, for the treatment of
metastatic prostate cancer and the trial is expected to complete by March 2020.
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Polymer-drug Conjugates Market
Restraint
Limited use of polymer-drug
conjugates is expected to restrain growth of the polymer-drug conjugates
market. For instance, according to an article published in Bioengineering and
Translational Medicine 2016, polymer-drug conjugates are formed by covalent
linkage between the drug and polymer and not all of the drugs have chemical
functional groups for covalent conjugation. Moreover, they offer triggered drug
release only at the tumor tissue or cell.
Lack of standard and optimized
preclinical or clinical protocols to evaluate polymer-drug conjugate stability,
tumor penetration, metabolism, and toxicity are hindering growth of the polymer-drug
conjugates market.
Polymer-drug Conjugates Market –
Regional Analysis
On the basis of region, the
global polymer-drug conjugates market is segmented into North America, Latin
America, Europe, Asia Pacific, Middle East, and Africa.
North America is projected to
hold dominant position in the global polymer-drug conjugates market due to
increase in number of clinical trials in the U.S. For instance, in January
2018, Apellis Pharmaceuticals announced to conduct phase III clinical study for
APL-2 in the U.S. APL-2 is a synthetic cyclic peptide drug conjugated to a
polyethylene glycol polymer for the treatment of geographic atrophy associated
with age-related macular degeneration.
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Furthermore, increasing research
on novel Drug Delivery Systems (DDS) in Asia Pacific is expected to contribute
to significant growth of the polymer drug conjugates market in the region
during the forecast period. For instance, in August 2018, Osaka University, in
collaboration with Tokyo Institute of Technology, Japan, developed a DDS using
polyethylene glycol and polylysine block copolymer, with ubenimex conjugate
(PEG-b-PLys (Ube). Intravenous injection of ubenimex with these polymers in
mice, found to reduce the tumor size significantly. Such results are expected
to be a positive traction for growth of the market during the forecast period.
Key players operating in
polymer-drug conjugates market include, Access Pharma, Abeona Therapeutics,
Inc., ADAMA India Private Limited, Avadel., GlaxoSmithKline plc. JenKem
Technology USA, Lipotek, Sansheng Pharmaceutical Group, Landec Corporation, and
Gowan Company.
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