Single Cell Genome Sequencing Market - Regional Insights
On the basis of Geography, Single
Cell Genome Sequencing Market is segmented into North America, Latin
America, Europe, Asia Pacific, Middle East, and Africa. North America is
expected to be dominant in the market during forecast period. High prevalence
of different types of cancer is witnessed in the U.S. According to a report by
American cancer Society, 2018, cancer is the second leading cause of death
after cardio vascular disease. The report further projected around 1.7 million
new cases of cancer with around half million deaths, worldwide.
Single cell genome sequencing
involves isolating a single cell and amplifying and sequencing genes within
that single cell. Sequencing single cell carries significant importance as
individual cells can differ at great extent in size, protein levels, and
expressed RNA transcripts. These variations could provide important insights
about several research applications such as cancer research, stem cell biology,
immunology, developmental biology, and neurology. Single-cell analysis enables
a closer view of the gene expression of individual cells to understand their
functions in complex tissues.
Kits and instruments based on
technological platform such as Next Generation Sequencing (NGS), polymerase
chain reaction (PCR), quantitative polymerase chain reaction (qPCR), and others
provide high-throughput sequencing of individual cells. Single cell sequencing
has significantly evolved with in-depth understanding of genomes and increasing
genomic research to trace the root cause of many chronic diseases.
Single Cell Genome Sequencing
Market Dynamics
Single cell genome sequencing is
one of most focused area of research for finding cure for chronic disease such
as cancer as it could help to observe tumor microenvironment. According to
World Health Organization (WHO), cancer is one of leading non-communicable
disease and second leading cause of death, worldwide. According to a report by
International Age for Research on Cancer (IARC) in 2012, around 14.1 million
new cases of cancer were registered with around 8.8 million death and around
32.6 million people are living with cancer in the year 2012.
Introduction of new therapies for
the treatment of cancer such as personalized medicine (Immuno-oncology and
others.) is expected to increase the adaption of single cell genomic sequencing
for advancing research in order to observe cellular level changes in cancer
cells.
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Furthermore, application of
single cell genomic sequencing in other diseases such as immune system disorder
and infectious diseases (Tuberculosis, meningococcal disease, and others.) is a
key factor contributing to the market growth. According to statistics given by
Centers for Disease Control and Prevention 2017 Vital Signs, around 54.4
million U.S. adults suffer from arthritis – which is equivalent to 25% of the
U.S. population. Rheumatoid arthritis which is leading autoimmune disorder
holds significant share in the overall arthritis prevalence.
Continuous development in
sequencing technologies is further expected to propel growth of the single cell
genome sequencing market. PCR and next generation sequencing are rapidly
emerging as preferred technology for several applications including single cell
genomic sequencing. For instance, Oxford Nanopore, in 2017, launched two
sequencing kits— for direct or PCR cDNA analysis that facilitate easy use and
provide results in reduced time and cost.
Several collaborations amongst
commercial companies and academic and research institutes is expected to propel
the single cell genome sequencing market growth. For instance, in 2015, three
single cell genomics centers were started in Sweden, Australia and the U.S—with
an objective to facilitate R&D activities in single cell genome sequencing.
The center in Australia was started with collaboration of Monash University,
the University of Melbourne, the University of Newcastle and the Hudson
Institute of Medical Research, and Fluidigm Corporation.
Single cell genome sequencing is
utilized by several research institutes and commercial companies for revealing
changes at gene level in single cell which could lead to potential therapies
and access to develop new medicines.
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Moreover, key players that offer
cutting edge technologies such as NGS technology, q PCR technology and high
commercial and academic research spending are present in the U.S, which is
expected to accelerate the market growth.
Single Cell Genome Sequencing
Market - Competitive Landscape
Key players operating in the
single cell genome sequencing market include, Illumina, Inc., Fludigim
Corporation, Thermo Fisher Scientific, F. Hoffmann-La Roche Ltd., Inc., QIAGEN,
Bio-Rad Laboratories, 10x Genomics, Novogene, BGI, Oxford Nanopore Technologies,
and Pacific Biosciences
Companies are focused on new
product launches and collaborations to extend their market share. For instance,
In January 2018, Illumina
launched semiconductor-based sequencing system—iSeq 100t that uses
sequencing-by-synthesis chemistry coupled with CMOS detection technology.
In June 2018, QIAGEN launched
QIAseq 16S/ITS Panels and UCP Multiplex PCR Kit with a new generation of
reagents that enables the most accurate microbial community profiling from
complex microbiome samples and is used for single cell sequencing.
In January 2018, Thermo Fisher
Scientific and Illumina Inc. entered commercial agreement, under which Illumina
could sell Ion AmpliSeq technology to researchers who conduct scientific
studies on Illumina’s next-generation sequencing (NGS) platforms.
In 2017, Illumina Inc. and
Bio-Rad Laboratories, Inc. launched the Illumina Bio-Rad Single-Cell Sequencing
Solution. It is the first next-generation sequencing (NGS) workflow for
single-cell analysis, which would enable researcher investigate the role of
single cells in tissue function, disease progression, and therapeutic response.
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