Accurate Dosing is Essential in
Atomization
Since then there have been many
new devices being introduced in the Nasal
Atomizer Devices Market with improving dosage accuracy. Accurate dosing is
essential in a nasal atomization device to circumvent any side effects due to
overdose. Recently in November 2016, Teleflex Medical Corporation recalled its
MAD Nasal Intranasal Mucosal atomization device which contained drug to reverse
the action of opioid overdose. The device was recalled on the warning that it
may not deliver the proper dose of the drug naloxone hydrochloride. This drug
with the device is extensively used by the policemen and firefighters in the
U.S.
The market still in its nascent
stages of adoption is experiencing increasing acceptance in the developed
regions of North America and Europe. However, creating awareness among the
healthcare professionals and patients is essential for acceptance of this novel
technology. Increasing self-medication trend can be leveraged upon for
penetrating the global nasal drug delivery devices market.
Major market players include
DeVilbiss Healthcare, Teleflex Incorporated, and Kurve Technology, etc. Being a
niche segment of drug delivery, there exists a lot potential for manufacturers
of nasal drug delivery systems.
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Nasal delivery is a choice of
treatment or drug delivery for the topical treatment of nasal diseases and
paranasal sinuses like sinusitis and allergic rhinitis. Moreover, the nasal
route is considered in some cases over the normal oral route owing to rapid
absorption and needle-free drug delivery with the effect as desired. Hence, it
is also one of the preferred routes for needle-free vaccination and systemic
drug delivery. Moreover, this route helps addressing issues related to poor
bioavailability, slow absorption, drug degradation and adverse events in the
gastrointestinal tract. Atomized nasal medications rapidly absorb across
mucosal membranes into the bloodstream, avoiding first-pass metabolism.
However, during nasal delivery one needs to take care to protect the delicate
lungs from hazardous exposures. Medication in liquid form can be administered
via nasal route through inhalers, spray pumps, droppers, nebulizers or
atomizers. In atomizers the medication exits the tip as a fine atomized mist
resulting in broad coverage of the nasal mucosal with a thin layer of drug.
Nasal Atomizer Device Types
Nasal atomizers are currently
used in the treatment of allergic rhinitis and sinusitis. These devices usually
are multi-dose products enabling long-term usage of the device. The nasal
atomizers are classified based on the technology/mechanics as gas propelled or
electrical. The air or gas controlled technique involves the use of squeezed
bottle which when pressed releases the content out of the small nozzle in
definite volume. The dose delivered however is highly dependent on the pressure
applied while squeezing the bottle. An electronic atomizer on the other hand is
devised to release only a defined amount of medication from the nozzle. This
makes the use of device more convenient for patients at home.
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Kurve Technology had designed and
developed a nasal drug delivery device called ViaNase in 2004 that used a
controlled particle dispersion method. During that period, Kurve’s technology
was the only known technique that delivered chemical formulations via the nose
to the paranasal sinuses in clinical testing. Moreover, Kurve’s technology was
also designed to be used with multiple drugs.
Key Developments
Increasing availability of drug
in the form of a nasal atomizer is expected to boost the market growth. For
instance, Naloxone, a drug known to reverse the effects of an opioid overdose,
was made available online in Louisiana, in the form of a nasal atomizer. It was
made available on www.naloxoneexchange.com, a website by Script Health, a
Public Benefit Corporation.
Research on use of nasal devices
is expected to offer growth opportunities for market players. For instance,
according to a study from the National Institute on Drug Abuse (NIDA), March
2019, improvised nasal naloxone devices commonly used by first responders and
the general public deliver significantly less naloxone than regulator-approved
devices.
Major companies are also focused
on gaining contracts to enhance their market share. For instance, in May 2019,
Kurve Technology, developer of ViaNase electronic atomizer, won the U.S.
Department of Defense’s contract for testing a new formulation in combatting
traumatic brain injuries.
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