Bone
degeneration is characterized by deterioration of articular cartilage
covering the joints. Cartilage aids free movement of the joint
without any resistance. Reduction in flexibility of the joint due to
deterioration of cartilage leads to inflammation, compressed nerves,
and pain. Aging is one of the natural causes of bone degeneration,
which is also fueled by several conditions such as injuries,
congenital disorders, diabetes, and obesity. Symptoms of degenerative
bone disorders includes joint stiffness, radiating pain that
initiates in the back and spreads through the extremities and causes
joint inflammation.
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Osteoporosis
– characterized by existence of porous bones may lead to fractures
There
are two levels of bone loss that can result in an increased risk of
fractures. Osteoporosis and osteopenia constitute two levels of bone
loss. Osteopenia is considered as loss of bone material density,
which indicates thinning of bones. Osteoporosis is a bone
degeneration condition characterized by the existence of porous bones
and it develops with time as bones slowly lose minerals, structure,
and density, resulting in weaker bones. Eventually, osteoporosis
leads to bent posture, cracked bones, and loss of height.
Excessive
bone degeneration results in fragile bones that are highly
susceptible to fracture. There are several tests such as bone
densitometers and dual energy x-ray absorptiometry scans performed to
determine the density of bones. Stimulation of soft tissues and
cartilage repair with prolotherapy represents some of the ways of
alleviating pain resulting from degenerative bone disorders.
Increasing
diabetes incidence and rising obesity driving growth of the bone
degeneration therapeutics market
Factors
such as increased physical inactivity, rising obesity, and increasing
rate of diabetes are fueling growth of the bone degeneration
therapeutics market. According to World Health Organization (WHO)
around 422 million people worldwide suffered from diabetes in 2014.
Increasing number of diabetic patients is fueling growth of the bone
degeneration therapeutics market.
Various
products in research pipeline to augment the bone degeneration
therapeutics market growth
Bone
degeneration therapeutics market can be segmented by treatment and
application. By treatment, the bone degeneration therapeutics market
can be segmented into device, drug, and surgery. Braces or sleeves
are used to relieve pain caused due to bone degeneration. These
provide pain relief to orthopedic patients. By drug, the bone
degeneration therapeutics market is segmented into cortisone or
steroids, hyaluronic acid and platelet-rich plasma. Platelet-rich
plasma is effective in alleviating pain resulting from arthritis of
the knee. Some products such as PREOB and ALLOB (both from Bone
Therapeutics SA) are in research pipeline. PREOB received orphan drug
designation for osteonecrosis in March 2008 from the U.S. FDA. On the
basis of surgery, the bone degeneration therapeutics market is
classified as arthroscopy, high tibial osteotomy, and knee
replacement. By application, the bone degeneration therapeutics
market can be segmented as osteoporosis, osteopenia, and spinal
fusion.
Bone
degeneration market: Key players
Amgen,
Inc., Fate Therapeutics, Inc., Bone Therapeutics SA, Juventus
Therapeutics, Inc., Kaken Pharmaceutical Co., Ltd., Regenexx, and
Se-cure Pharmaceuticals, Ltd. are some of the companies involved in
development of bone degeneration therapeutic products. Regenexx stem
cell and platelet-rich plasma procedures are advanced regenerative
injection treatment used to treat knee pain due to arthritis,
ligament injuries, and other degenerative conditions.
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