Tissue
plasminogen activator (tPA) is an enzyme associated with the
disintegration of blood clots. It is a serine protease present in
endothelial cells. With the help of serine protease, the conversion
of plasminogen to plasmin is catalyzed. Serine protease is a major
enzyme for clot disintegration.
tPA
is also be produced by using recombinant technology techniques known
as recombinant tissue plasminogen activator (rtPA). Specific rtPAs
are tenecteplase, alteplase, and reteplase. These enzymes are used in
clinical treatment of thrombotic stroke or embolic stroke. tPA is a
drug that dissolves blood clots. It is a thrombolytic agent which can
be administrated into the veins.
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Global
Tissue Plasminogen Activator Market: Drivers
Tissue
plasminogen activator is the first and only drug approved by the FDA
in 1996 for the treatment of acute ischemic stroke. Increasing
incidences of stroke has boosted the tissue plasminogen activator
market size. According to John Hopkins Medicines (JHM) in the U.S.,
around 795,000 people in the U.S. suffer from stroke per year, as
reported in 2014. According to the World Health Organization (WHO),
stroke is the second leading cause of death and the third leading
cause of disability, worldwide, as reported in 2012. This is one of
the major factors driving the tissue plasminogen activator market
growth.
Global
Tissue Plasminogen Activator Market: Regional Analysis
North
America is the leader in the global tissue plasminogen activator
market, owing to rising awareness about stroke and huge spending on
treatment of stroke. For instance, in 2017, the American Heart
Association (AHA) recorded stroke costs as US$ 34 billion in the U.S.
every year, which includes medicines for the treatment of stroke and
cost of health care services.
Asia
pacific is the fastest growing region in the tissue plasminogen
activator market, owing to increasing demand drug coupled with rising
stroke incidences in the region. According to WHO, Indonesia,
Philippines, China, and India have highest rates of stroke, which is
186.3, 134.7, 128, and 71.5, respectively, as recorded in 2017.
Global
Tissue Plasminogen Activator Market: Competitive Landscape
Key
players operating in the global tissue plasminogen activator market
include Bayer AG, Abcam, Calbiochem, Merck & Company, Roche,
Sekisui Diagnostics, Genentech, Sigma-Aldrich, Taj Pharmaceuticals,
and Cadila Healthcare Ltd.
Global
Tissue Plasminogen Activator Market: Taxonomy
The
global tissue plasminogen activator market is segmented on the basis
of dosage, route of administration, application, and region.
By
Route of administration:
-
Intravenous
-
Regional intra-arterial
By
Application:
-
Blood clots
-
Pulmonary embolism
-
Myocardial infarction
-
Stroke
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