North America and Asia Pacific
are expected to hold large Mesenchymal
Stem Cells Market shares followed by Europe due to the rapid growth in
technological innovations, high disposable incomes, and the well-equipped
healthcare centers, which will lead to the growth and development of MSCs
market. The implantation of new mesenchymal stem cells in cancer patients is
expected to enhance the growth of MSCs market.
As per the World Health
Organization (WHO) 2018 Factsheet, Cancer is the second leading cause of death
globally, and it caused around 9.6 million deaths in 2018 globally. According
to the European Journal of Cancer, Europe witnessed over 3.9 million cases of
cancer and around 1.9 million deaths from cancer in the year 2018. Whereas,
according to National Center for Biotechnology Information (NCBI), in Asia
Pacific, breast cancer in females was found to be around 18.0% in the year 2012
and it was the fourth most cause for around 9% death due to cancer in the
region.
Mesenchymal stem cells, also
known as Mesenchymal Stromal Cells (MSCs), are adult, fibroblast-like
multipotent cells that can differentiate and mature into tissues of mesodermal
origin such as adipocytes, chondroblasts, and osteoblasts. Mesenchymal stem
cells were isolated first time from the bone marrow and later from various
sources such as cord cells, adipose tissue, and molar cells. MSCs in terms of
size, are smaller and are quite difficult to observe in histological sections.
A group of mesenchymal stem cells are called as mesenchyme and is widely
distributed in the body. Mesenchymal cells can multiply in numbers of
specialized cells and they can grow in-vitro or in-vivo condition.
The mesenchymal stem cells play
an important role within an organism for suppression of immune cells
activation, increase the number of newer cells, reduce cell death or cell
damage in the body, and secretion of both neurotrophic and angiogenic factors,
which are responsible for stabilizing the extracellular matrix, when
transplanted to the brain, this cells promote the reduction of free radical
levels and enhance synaptic connections of damaged neurons, and increases the
myelination of axons. The mesenchymal cells are also able to replace and repair
any damaged blood vessel in the cerebrum brain.
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Rise in prevalence of
osteoporosis and increase in cancer incidences are expected to support the
global market growth
MSCs have the ability to grow
bone tissues through the bone surface to form new bone, which in turn has the
potency to treat osteoporosis. According to the National Institute of Health
(NIH), in 2015, the U.S. accounted for around 53 million people suffering from
osteoporosis or at a high risk due to low bone mass.
According to Osteoporosis Canada,
around 1 in 5 men and 1 in 3 women suffer from osteoporotic fracture during
their lifetime, whereas osteoporosis causes around 70-90% of 30,000 hip
fractures yearly; the annual cost to Canada for treating osteoporosis was
around US$ 4.0 billion in the year 2012, which is expected to rise in the
upcoming years. Furthermore, according to the International Osteoporosis
Foundation (IOF), annually around 9.0 million people worldwide are suffering
from osteoporosis fractures. The aforementioned factors are expected to bolster
the Mesenchymal stem cells market growth over the forecast period.
Mesenchymal Stem Cells Market
Players
Key players in the market are
focusing on inorganic growth strategies such as acquisition and collaboration
in order to expand its research and development activities and geographical
presence. For instance in February 2019 Pluristem Therapeutics has collaborated
with the NASA's Ames Research Center to evaluate the potential of Pluristem's
PLX cell therapies in preventing and treating medical conditions caused during
space missions.
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During space mission astronauts
are exposed to a challenging environment that includes radiation and
microgravity, leading to muscle and bone loss as well as other potentially
serious medical conditions. The collaboration will explore the possibility that
PLX placenta-based cell therapy products can address these and other persistent
negative effects of space travel on the human body.
In February 2019, BrainStorm Cell
Therapeutics Inc. announced to expand its clinical trial facility with
Cleveland Clinic as the first U.S. clinical site contracted for a planned Phase
2 open-label, multicenter study of repeated intrathecal administration of
autologous Mesenchymal Stem Cell (MSC-NTF) cells in participants with progressive
Multiple Sclerosis (MS).
Moreover most of the key players
are focusing on new product launch in the global mesenchymal stem cell market.
For instance in February 2019, Cytonus Therapeutics has developed Cargocytes a
first-of-its-kind, controllable, cell-based platform technology for delivery of
biologics. Cargocytes are engineered allogenic cell lines that can carry a
variety of small molecule compounds, gene editing therapies, therapeutic RNAs,
and powerful biologics such as immune modulating cytokines, antibodies and
oncolytic viruses. As a platform technology, cargocyte has many therapeutic
applications and will be commercialized through a blend of internal and partnered
programs.
Some of the key market players
identified across the value chain of mesenchymal stem cells market are,
Pluristem Therapeutics, LonzaThermo, Fisher, ATCC, Bio-Techne, MilliporeSigma,
Genlantis, Celprogen, Cell Applications, PromoCell GmbH, Cyagen Biosciences,
Human Longevity Inc., Axol Bioscience, Cytori Therapeutics, Eutilex Co.Ltd., ID
Pharma Co. Ltd., BrainStrom Cell Therapeutics, Cytori Therapeutics Inc., Neovii
Biotech, Angel Biotechnology, California Stem Cell Inc., Stemcelltechnologies Inc.,
and Celgene Corporation Inc.
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