Gel
permeation chromatography is size exclusion technique used for
separation and characterization of polymers. It is an exclusive
technique to perform polymer characterization, in order to assess the
molecular weight distribution of an analyte. Profiling of the polymer
is important as it affects physical properties such as brittleness,
elasticity, and toughness in its end use. Gel permeation
chromatography system is based on principle that different component
shows different affinity towards stationary phase (Column Packing
material). Smaller component gets trapped in the pores of the packing
material therefore, these show high retention time. On the other
hand, larger component in analyte surpasses stationary phase without
much affinity therefore, has lower retention time. Based on this
data, processing unit shows varying peaks on display according to
which cauterization and separation of the analyte can be done. Gel
permeation chromatography system consists of various component such
as pump system, injector system, columns, detectors, and data
proceeding systems.
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The
global gel permeation chromatography system was valued at US$ 929.2
million in 2016 and is expected to witness a robust CAGR of 7.0% over
the forecast period (2017–2025).
Top
Players
Key
players operating in gel permeation chromatography market are Agilent
Technologies, Waters Corporation, Malvern Panalytical, Shimadzu
Corporation, and Polymer Char.
Increasing
research and development by pharmaceutical and biotech companies in
chronic disease is expected to propel growth of the gel permeation
chromatography market
Increasing
focus on research and development activities by pharmaceutical and
biotech companies across the globe, targeting chronic diseases such
as cancer to bring novel therapies, is expected to aid in growth of
the market. These are protein (Natural Polymer) based therapies such
as CAR-T cell therapy, antibody-drug conjugates, and immune check
point inhibitors. According to report in 2017 by International
Federation of Pharmaceutical Manufacturers and Associations, research
based pharmaceutical and biotech companies annually invest around US$
149 billion on research and development. Over 7,000 molecule are
under investigation, out of which around 2,000 candidate are for
cancer. Therefore, separation and characterization of new chemical
entity, which are polymer-based is possible efficiently with gel
permeation chromatography and this is expected to aid in growth of
the market in the near future.
Regulatory
approvals for use of novel excipients (Polymers) is expected to drive
growth of the gel permeation chromatography market
Pharmaceutical
and biotech companies widely use polymers as excipient (Binder,
Diluent, coating agents, suspending agent, viscosity agent, and
Disintegrant) to produce variety of dosage form. There is increasing
use of natural polymers instead of synthetic one due to inertness,
low cost, and higher acceptability of consumers towards natural
polymers. Various recently launched natural polymers from different
manufacturers are Solutol HS 15, Soluplus, Kollicoat Smartseal 30 D,
Polyplasdone Ultra, and Prosolv ODT.
Detailed
Segmentation:
Global
Gel Permeation Chromatography Market, By Product Type:
-
Gel Permeation Chromatography System
-
Detectors
-
Columns
-
Pumps
Global
Gel Permeation Chromatography Market, By End User:
-
Pharmaceutical and Biotech Companies
-
Research Institutes
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